DSE - Dermatan-sulfate epimerase - human protein (Function)
 
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DSE »  Dermatan-sulfate epimerase   [ EC 5.1.3.19 ]  (DS epimerase)
 
Protein also known as:  Squamous cell carcinoma antigen recognized by T-cells 2 (SART-2).
Gene name:  DSE
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.  
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  • CuratedUniProtKB
GO molecular function 
Chondroitin-glucuronate 5-epimerase activitydefinition[GO:0047757]  
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  • IDAHGNC
GO biological process 
Chondroitin sulfate biosynthetic processdefinition[GO:0030206]  
  • IEAUniPathway
Dermatan sulfate biosynthetic processdefinition[GO:0030208]  
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  • IDAUniProtKB
Heparan sulfate proteoglycan biosynthetic processdefinition[GO:0015012]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.1.3.19: Chondroitin D-glucuronate dermatan L-iduronate.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathways
According to KEGG, this protein belongs to the following pathway:
Glycosaminoglycan biosynthesis - chondroitin sulfate  hsa00532+29940  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DSE_(gene)
GenomeRNAi: 29940
PRO: PR:Q9UL01