TBX21 - T-box transcription factor TBX21 - human protein (Function)
 
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TBX21 »  T-box transcription factor TBX21  (T-box protein 21)
 
Protein also known as:  T-cell-specific T-box transcription factor T-bet.
Gene name:  TBX21
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.  
  • CuratedUniProtKB
GO molecular function 
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Lymphocyte migrationdefinition[GO:0072676]  
1
  • IDAUniProtKB
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASUniProtKB
Positive regulation of isotype switching to IgG isotypesdefinition[GO:0048304] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • TASUniProtKB
Response to virusdefinition[GO:0009615]  
1
  • IEPUniProtKB
T cell differentiationdefinition[GO:0030217] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TBX21
GenomeRNAi: 30009
PRO: PR:Q9UL17