RAB21 - Ras-related protein Rab-21 - human protein (Function)
 
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RAB21 »  Ras-related protein Rab-21
 
Gene name:  RAB21
Family name: Small GTPase » Rab
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity).  
3
  • UniProtKB
GO molecular function 
GDP bindingdefinition[GO:0019003]  
2
  • UniProtKB
GTP bindingdefinition[GO:0005525]  
2
  • UniProtKB
GTPase activitydefinition[GO:0003924]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
GO biological process 
Intracellular protein transportdefinition[GO:0006886]  
1
  • RefGenome
Metabolic processdefinition[GO:0008152]  
1
  • GOC
Positive regulation of early endosome to late endosome transportdefinition[GO:2000643]  
1
  • UniProtKB
Positive regulation of receptor-mediated endocytosisdefinition[GO:0048260]  
1
  • UniProtKB
Rab protein signal transductiondefinition[GO:0032482]  
1
  • RefGenome
Regulation of exocytosisdefinition[GO:0017157]  
1
  • UniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RAB21
GenomeRNAi: 23011
PRO: PR:Q9UL25