RAB21 - Ras-related protein Rab-21 - human protein (Function)
 
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RAB21 »  Ras-related protein Rab-21
 
Gene name:  RAB21
Family name: Small GTPase » Rab
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis.  
2
  • UniProtKB
GO molecular function 
GDP bindingdefinition[GO:0019003]  
2
  • UniProtKB
GTP bindingdefinition[GO:0005525]  
2
  • UniProtKB
GTPase activitydefinition[GO:0003924]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
GO biological process 
GTP catabolic processdefinition[GO:0006184]  
1
  • GOC
Intracellular protein transportdefinition[GO:0006886]  
1
  • RefGenome
Positive regulation of early endosome to late endosome transportdefinition[GO:2000643]  
1
  • UniProtKB
Positive regulation of receptor-mediated endocytosisdefinition[GO:0048260]  
1
  • UniProtKB
Rab protein signal transductiondefinition[GO:0032482]  
1
  • RefGenome
Regulation of endocytosisdefinition[GO:0030100]  
1
  • RefGenome
Regulation of exocytosisdefinition[GO:0017157]  
1
  • UniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RAB21
GenomeRNAi: 23011
PRO: PR:Q9UL25