HCN2 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 - human protein (Function)
 
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HCN2 »  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
 
Protein also known as:  Brain cyclic nucleotide-gated channel 2 (BCNG-2).
Gene name:  HCN2
Family name: Potassium channel HCN
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).  
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  • UniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.5.11  
GO molecular function 
cAMP bindingdefinition[GO:0030552]  
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  • UniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
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  • IntAct
Intracellular cAMP activated cation channel activitydefinition[GO:0005222]  
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  • UniProtKB
Voltage-gated potassium channel activitydefinition[GO:0005249]  
3
  • UniProtKB
  • RefGenome
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • UniProtKB
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
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  • PINC
Cellular response to cAMPdefinition[GO:0071320]  
2
  • UniProtKB
Cellular response to cGMPdefinition[GO:0071321]  
1
  • UniProtKB
Potassium ion transmembrane transportdefinition[GO:0071805]  
3
  • UniProtKB
  • RefGenome
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Regulation of membrane potentialdefinition[GO:0042391]  
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  • UniProtKB
  • RefGenome
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • UniProtKB
Enzymatic activity 
It is regulated in the following manner
Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. CAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. Channel activity is modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.  
3
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
HCN channels  REACT_75862  
Note 
Inhibited by extracellular cesium ions.  
1
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Potassium channel  definition   [KW-0631]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HCN2
GenomeRNAi: 610
PRO: PR:Q9UL51
Chemistry
GuidetoPHARMACOLOGY: 401