HCN2 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 - human protein (Function)
 
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HCN2 »  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
 
Protein also known as:  Brain cyclic nucleotide-gated channel 2 (BCNG-2).
Gene name:  HCN2
Family name: Potassium channel HCN
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 28 1
GENE REF ISO

Function

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Overview 
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.5.11  
GO molecular function 
cAMP bindingdefinition[GO:0030552]  
  • IEAUniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Intracellular cAMP activated cation channel activitydefinition[GO:0005222]  
1
  • IDAUniProtKB
Voltage-gated potassium channel activitydefinition[GO:0005249]  
2
  • IMPUniProtKB
  • IBARefGenome
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • IMPUniProtKB
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cellular response to cAMPdefinition[GO:0071320]  
2
  • IDAUniProtKB
Cellular response to cGMPdefinition[GO:0071321]  
1
  • IDAUniProtKB
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • IMPUniProtKB
  • IBARefGenome
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IMPUniProtKB
  • IBARefGenome
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • IMPUniProtKB
Enzymatic activity 
It is regulated in the following manner
Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. CAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. Channel activity is modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.  
2
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
Note 
Inhibited by extracellular cesium ions.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Potassium channel  definition   [KW-0631]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HCN2
GenomeRNAi: 610
PRO: PR:Q9UL51
Chemistry
GuidetoPHARMACOLOGY: 401