TRPC5 - Short transient receptor potential channel 5 - human protein (Function)
 
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TRPC5 »  Short transient receptor potential channel 5  (TrpC5)
 
Protein also known as:  Transient receptor protein 5 (TRP-5).
Gene name:  TRPC5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.1.7  
GO molecular function 
Calcium channel activitydefinition[GO:0005262]  
1
  • IDAUniProtKB
Inositol 1,4,5 trisphosphate bindingdefinition[GO:0070679] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Store-operated calcium channel activitydefinition[GO:0015279]  
1
  • TASPINC
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
1
  • TASPINC
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Enzymatic activity 
It is regulated in the following manner
Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPC5
GenomeRNAi: 7224
PRO: PR:Q9UL62
Chemistry
GuidetoPHARMACOLOGY: 490