RAB23 - Ras-related protein Rab-23 - human protein (Function)
 
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RAB23 »  Ras-related protein Rab-23
 
Gene name:  RAB23
Family name: Small GTPase » Rab
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.  
3
  • UniProtKB
GO molecular function 
GDP bindingdefinition[GO:0019003]  
1
  • RefGenome
GTP bindingdefinition[GO:0005525]  
1
  • RefGenome
GTPase activitydefinition[GO:0003924]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Autophagic vacuole assemblydefinition[GO:0000045]  
1
  • UniProtKB
Cellular defense responsedefinition[GO:0006968]  
1
  • UniProtKB
Cilium assemblydefinition[GO:0042384]  
1
  • UniProtKB
Craniofacial suture morphogenesisdefinition[GO:0097094]  
1
  • UniProtKB
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
1
  • Ortholog Compara
GTP catabolic processdefinition[GO:0006184]  
2
  • UniProtKB
Negative regulation of proteolysisdefinition[GO:0045861] silver  
1
  • Ortholog Compara
Negative regulation of transcription factor import into nucleusdefinition[GO:0042992]  
1
  • UniProtKB
Protein transportdefinition[GO:0015031]  
1
  • UniProtKB KW
Rab protein signal transductiondefinition[GO:0032482]  
1
  • RefGenome
Regulation of smoothened signaling pathwaydefinition[GO:0008589] silver  
1
  • Ortholog Compara
Spinal cord dorsal/ventral patterningdefinition[GO:0021513] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Hedgehog signaling pathway  hsa04340+51715  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RAB23
GenomeRNAi: 51715
PRO: PR:Q9ULC3