ACSL5 - Long-chain-fatty-acid--CoA ligase 5 - human protein (Function)
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ACSL5 »  Long-chain-fatty-acid--CoA ligase 5   [ EC ]
Protein also known as:  Long-chain acyl-CoA synthetase 5 (LACS 5).
Gene name:  ACSL5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 3


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Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Long-chain fatty acid-CoA ligase activitydefinition[GO:0004467]  
  • IDAUniProtKB
  • IEAEC 2 GO
GO biological process 
Long-chain fatty acid metabolic processdefinition[GO:0001676]  
  • IDAUniProtKB
  • IEAEC 2 GO
Isoform  Iso 1   Regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001236]  
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + a long-chain fatty acid + CoA AMP + diphosphate + an acyl-CoA.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+51703  
Fatty acid metabolism  hsa00071+51703  
Metabolic pathways  hsa01100+51703  
Peroxisome  hsa04146+51703  
PPAR signaling pathway  hsa03320+51703  
According to Reactome, this protein belongs to the following pathway:
Synthesis of very long-chain fatty acyl-CoAs  REACT_380  
More information is available from:

Biophysicochemical properties

Kinetic parameters
KM 0.11 uM for palmitic acid (isoform 1 at pH 7.5)
KM 0.04 uM for palmitic acid (isoform 3 at pH 7.5)
KM 0.38 uM for palmitic acid (isoform 1 at pH 9.5)
KM 0.15 uM for palmitic acid (isoform 3 at pH 8.5)
pH Optimum pH is 9.5 (isoform 1), 7.5-8.5 (isoform 3).


Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: ACSL5
GenomeRNAi: 51703