ASAP1 - Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 - human protein (Function)
 
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ASAP1 »  Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
 
Protein also known as:  130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein.
Gene name:  ASAP1
Entry whose protein(s) existence is based on evidence at protein level
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1 51 2
GENE REF ISO

Function

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Overview 
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.  
1
  • CuratedUniProtKB
GO molecular function 
ARF GTPase activator activitydefinition[GO:0008060] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
10
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cilium morphogenesisdefinition[GO:0060271]  
1
  • IMPUniProtKB
Positive regulation of GTPase activitydefinition[GO:0043547]  
  • IEAInterPro 2 GO
  • IEAUniProtKB KW
Regulation of ARF GTPase activitydefinition[GO:0032312] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
It is regulated in the following manner
Activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Endocytosis  hsa04144+50807  
Fc gamma R-mediated phagocytosis  hsa04666+50807  
 

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DDEF1
GenomeRNAi: 50807
PRO: PR:Q9ULH1