VANGL2 - Vang-like protein 2 - human protein (Function)
 
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Protein
Gene
References

 
VANGL2 »  Vang-like protein 2
 
Protein also known as:  Loop-tail protein 1 homolog.
Gene name:  VANGL2
Family name: Vang
Entry whose protein(s) existence is based on evidence at protein level
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1 29 1
GENE REF ISO

Function

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Overview 
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity).  
  • CuratedUniProtKB
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
Apical protein localizationdefinition[GO:0045176]  
  • ISSOrtholog Curator
Cell migration involved in kidney developmentdefinition[GO:0035787]  
  • ISSOrtholog Curator
Cochlea morphogenesisdefinition[GO:0090103] silver  
  • IEAOrtholog Compara
Convergent extension involved in axis elongationdefinition[GO:0060028] silver  
  • IEAOrtholog Compara
Convergent extension involved in neural plate elongationdefinition[GO:0022007] silver  
  • IEAOrtholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
  • IEAOrtholog Compara
Establishment of body hair planar orientationdefinition[GO:0048105] silver  
  • IEAOrtholog Compara
Establishment of planar polaritydefinition[GO:0001736]  
  • ISSOrtholog Curator
Establishment of planar polarity involved in neural tube closuredefinition[GO:0090177] silver  
  • IEAOrtholog Compara
Establishment or maintenance of epithelial cell apical/basal polaritydefinition[GO:0045197] silver  
  • IEAOrtholog Compara
Glomerulus developmentdefinition[GO:0032835] silver  
  • IEAOrtholog Compara
Hair follicle developmentdefinition[GO:0001942] silver  
  • IEAOrtholog Compara
Heart loopingdefinition[GO:0001947]  
  • ISSOrtholog Curator
Inner ear receptor stereocilium organizationdefinition[GO:0060122] silver  
  • IEAOrtholog Compara
Kidney morphogenesisdefinition[GO:0060993] silver  
  • IEAOrtholog Compara
Lateral sprouting involved in lung morphogenesisdefinition[GO:0060490] silver  
  • IEAOrtholog Compara
Membranous septum morphogenesisdefinition[GO:0003149] silver  
  • IEAOrtholog Compara
Muscular septum morphogenesisdefinition[GO:0003150] silver  
  • IEAOrtholog Compara
Neural tube closuredefinition[GO:0001843]  
  • ISSOrtholog Curator
Nonmotile primary cilium assemblydefinition[GO:0035058]  
  • ISSOrtholog Curator
Orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesisdefinition[GO:0060488] silver  
  • IEAOrtholog Compara
Planar cell polarity pathway involved in axis elongationdefinition[GO:0003402] silver  
  • IEAOrtholog Compara
Planar cell polarity pathway involved in neural tube closuredefinition[GO:0090179] silver  
  • IEAOrtholog Compara
Planar dichotomous subdivision of terminal units involved in lung branching morphogenesisdefinition[GO:0060489] silver  
  • IEAOrtholog Compara
Positive regulation of JUN kinase activitydefinition[GO:0043507] silver  
  • IEAOrtholog Compara
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
  • IEAOrtholog Compara
Regulation of actin cytoskeleton organizationdefinition[GO:0032956] silver  
  • IEAOrtholog Compara
Rho protein signal transductiondefinition[GO:0007266] silver  
  • IEAOrtholog Compara
Somatic stem cell divisiondefinition[GO:0048103] silver  
  • IEAOrtholog Compara
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Wound healingdefinition[GO:0042060] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Wnt signaling pathway  hsa04310+57216  
According to Reactome, this protein belongs to the following pathways:
Asymmetric localization of PCP proteins  REACT_172638  
PCP/CE pathway  REACT_172581  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 57216
PRO: PR:Q9ULK5