VANGL2 - Vang-like protein 2 - human protein (Function)
 
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Protein
Gene
References

 
VANGL2 »  Vang-like protein 2
 
Protein also known as:  Loop-tail protein 1 homolog.
Gene name:  VANGL2
Family name: Vang
Entry whose protein(s) existence is based on evidence at protein level
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1 32 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).  
2
  • UniProtKB
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
1
  • Ortholog Compara
Apical protein localizationdefinition[GO:0045176]  
1
  • Ortholog Curator
Cell migration involved in kidney developmentdefinition[GO:0035787]  
1
  • Ortholog Curator
Cochlea morphogenesisdefinition[GO:0090103] silver  
1
  • Ortholog Compara
Convergent extension involved in axis elongationdefinition[GO:0060028] silver  
1
  • Ortholog Compara
Convergent extension involved in neural plate elongationdefinition[GO:0022007] silver  
1
  • Ortholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
1
  • Ortholog Compara
Establishment of body hair planar orientationdefinition[GO:0048105] silver  
1
  • Ortholog Compara
Establishment of planar polaritydefinition[GO:0001736]  
1
  • Ortholog Curator
Establishment of planar polarity involved in neural tube closuredefinition[GO:0090177] silver  
1
  • Ortholog Compara
Establishment or maintenance of epithelial cell apical/basal polaritydefinition[GO:0045197] silver  
1
  • Ortholog Compara
Glomerulus developmentdefinition[GO:0032835] silver  
1
  • Ortholog Compara
Hair follicle developmentdefinition[GO:0001942] silver  
1
  • Ortholog Compara
Heart loopingdefinition[GO:0001947]  
1
  • Ortholog Curator
Inner ear receptor stereocilium organizationdefinition[GO:0060122] silver  
1
  • Ortholog Compara
Kidney morphogenesisdefinition[GO:0060993] silver  
1
  • Ortholog Compara
Lateral sprouting involved in lung morphogenesisdefinition[GO:0060490] silver  
1
  • Ortholog Compara
Membranous septum morphogenesisdefinition[GO:0003149] silver  
1
  • Ortholog Compara
Muscular septum morphogenesisdefinition[GO:0003150] silver  
1
  • Ortholog Compara
Neural tube closuredefinition[GO:0001843]  
1
  • Ortholog Curator
Nonmotile primary cilium assemblydefinition[GO:0035058]  
1
  • Ortholog Curator
Orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesisdefinition[GO:0060488] silver  
1
  • Ortholog Compara
Planar cell polarity pathway involved in axis elongationdefinition[GO:0003402] silver  
1
  • Ortholog Compara
Planar cell polarity pathway involved in heart morphogenesisdefinition[GO:0061346] silver  
1
  • Ortholog Compara
Planar cell polarity pathway involved in neural tube closuredefinition[GO:0090179] silver  
1
  • Ortholog Compara
Planar dichotomous subdivision of terminal units involved in lung branching morphogenesisdefinition[GO:0060489] silver  
1
  • Ortholog Compara
Positive regulation of JUN kinase activitydefinition[GO:0043507] silver  
1
  • Ortholog Compara
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
1
  • Ortholog Compara
Regulation of actin cytoskeleton organizationdefinition[GO:0032956] silver  
1
  • Ortholog Compara
Regulation of Wnt signaling pathwaydefinition[GO:0030111] silver  
1
  • Ortholog Compara
Rho protein signal transductiondefinition[GO:0007266] silver  
1
  • Ortholog Compara
Somatic stem cell divisiondefinition[GO:0048103] silver  
1
  • Ortholog Compara
Somatic stem cell maintenancedefinition[GO:0035019] silver  
1
  • Ortholog Compara
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Wnt signaling pathway  hsa04310+57216  
According to Reactome, this protein belongs to the following pathways:
Asymmetric localization of PCP proteins  REACT_264478  
PCP/CE pathway  REACT_264199  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 57216
PRO: PR:Q9ULK5