CNOT6 - CCR4-NOT transcription complex subunit 6 - human protein (Function)
 
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Protein
Gene
References

 
CNOT6 »  CCR4-NOT transcription complex subunit 6   [ EC 3.1.13.4 ]
 
Protein also known as:  Carbon catabolite repressor protein 4 homolog.
Gene name:  CNOT6
Family name: CCR4/nocturin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 1
GENE REF ISO

Function

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Overview 
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.  
4
  • CuratedUniProtKB
GO molecular function 
Exoribonuclease activitydefinition[GO:0004532]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Poly(A)-specific ribonuclease activitydefinition[GO:0004535]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723]  
  • IEAUniProtKB KW
GO biological process 
Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decaydefinition[GO:0043928]  
1
  • IDAUniProtKB
Gene silencing by miRNAdefinition[GO:0035195]  
1
  • TASUniProtKB
Nuclear-transcribed mRNA catabolic process, no-go decaydefinition[GO:0070966]  
1
  • IMPUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPUniProtKB
Positive regulation of cytoplasmic mRNA processing body assemblydefinition[GO:0010606]  
1
  • IMPUniProtKB
Positive regulation of ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:2000327]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Regulation of translationdefinition[GO:0006417]  
  • IEAUniProtKB KW
RNA phosphodiester bond hydrolysis, exonucleolyticdefinition[GO:0090503]  
2
  • IDAGOC
  • IEAEC 2 GO
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.13.4: Exonucleolytic cleavage of poly(A) to 5'-AMP.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA degradation  hsa03018+57472  
According to Reactome, this protein belongs to the following pathway:
Deadenylation of mRNA  REACT_20514  
 

Keywords

Biological process 
RNA-mediated gene silencing  definition   [KW-0943]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Translation regulation  definition   [KW-0810]
Molecular function 
Activator  definition   [KW-0010]
Exonuclease  definition   [KW-0269]
Hydrolase  definition   [KW-0378]
Nuclease  definition   [KW-0540]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CNOT6
GenomeRNAi: 57472
PRO: PR:Q9ULM6