TPCN1 - Two pore calcium channel protein 1 - human protein (Function)
 
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Protein
Gene
References

 
TPCN1 »  Two pore calcium channel protein 1
 
Protein also known as:  Voltage-dependent calcium channel protein TPC1.
Gene name:  TPCN1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 3
GENE REF ISO

Function

 show evidences
Overview 
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.  
1
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
NAADP-sensitive calcium-release channel activitydefinition[GO:0072345]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Voltage-gated calcium channel activitydefinition[GO:0005245] silver  
  • IBARefGenome
GO biological process 
Calcium ion transportdefinition[GO:0006816] silver  
  • IBARefGenome
Ion transmembrane transportdefinition[GO:0034220] silver  
  • IBARefGenome
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TPCN1
GenomeRNAi: 53373
PRO: PR:Q9ULQ1