FZD4 - Frizzled-4 - human protein (Function)
 
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FZD4 »  Frizzled-4  (Fz-4)
 
Protein also known as:  FzE4; CD antigen CD344.
Gene name:  FZD4
Entry whose protein(s) existence is based on evidence at protein level
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1 53 1
GENE REF ISO

Function

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Overview 
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  
  • CuratedUniProtKB
GO molecular function 
Cytokine bindingdefinition[GO:0019955]  
1
  • IPIBHF-UCL
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
PDZ domain bindingdefinition[GO:0030165]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
Wnt-activated receptor activitydefinition[GO:0042813]  
1
  • IDABHF-UCL
Wnt-protein bindingdefinition[GO:0017147] silver  
  • IBARefGenome
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Cellular response to retinoic aciddefinition[GO:0071300]  
  • ISSOrtholog Curator
Cerebellum vasculature morphogenesisdefinition[GO:0061301] silver  
  • IEAOrtholog Compara
Extracellular matrix-cell signalingdefinition[GO:0035426] silver  
  • IEAOrtholog Compara
Locomotion involved in locomotory behaviordefinition[GO:0031987] silver  
  • IEAOrtholog Compara
Negative regulation of cell-substrate adhesiondefinition[GO:0010812]  
1
  • IMPBHF-UCL
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
Positive regulation of JUN kinase activitydefinition[GO:0043507] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDABHF-UCL
Progesterone secretiondefinition[GO:0042701] silver  
  • IBARefGenome
Regulation of vascular endothelial growth factor receptor signaling pathwaydefinition[GO:0030947] silver  
  • IBARefGenome
Retina vasculature morphogenesis in camera-type eyedefinition[GO:0061299]  
2
  • IMPBHF-UCL
Retinal blood vessel morphogenesisdefinition[GO:0061304] silver  
  • IEAOrtholog Compara
Sensory perception of sounddefinition[GO:0007605] silver  
  • IEAOrtholog Compara
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446] silver  
  • IBARefGenome
Vasculogenesisdefinition[GO:0001570] silver  
  • IBARefGenome
Wnt signaling pathwaydefinition[GO:0016055]  
2
  • IDABHF-UCL
Wnt signaling pathway, calcium modulating pathwaydefinition[GO:0007223]  
1
  • IDABHF-UCL
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+8322  
HTLV-I infection  hsa05166+8322  
Melanogenesis  hsa04916+8322  
Pathways in cancer  hsa05200+8322  
Wnt signaling pathway  hsa04310+8322  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FZD4
GenomeRNAi: 8322
PRO: PR:Q9ULV1