FZD10 - Frizzled-10 - human protein (Function)
 
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FZD10 »  Frizzled-10  (Fz-10)
 
Protein also known as:  FzE7; CD antigen CD350.
Gene name:  FZD10
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  
1
  • UniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
  • IntAct
Wnt-activated receptor activitydefinition[GO:0042813] silver  
1
  • InterPro 2 GO
Wnt-protein bindingdefinition[GO:0017147]  
1
  • RefGenome
GO biological process 
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • RefGenome
Cellular response to retinoic aciddefinition[GO:0071300]  
1
  • Ortholog Curator
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Negative regulation of Rho GTPase activitydefinition[GO:0034259]  
1
  • BHF-UCL
Neuron differentiationdefinition[GO:0030182]  
1
  • Ortholog Curator
Non-canonical Wnt signaling pathway via JNK cascadedefinition[GO:0038031]  
1
  • BHF-UCL
Positive regulation of JUN kinase activitydefinition[GO:0043507]  
1
  • BHF-UCL
Positive regulation of Rac GTPase activitydefinition[GO:0032855]  
1
  • BHF-UCL
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+11211  
HTLV-I infection  hsa05166+11211  
Melanogenesis  hsa04916+11211  
Pathways in cancer  hsa05200+11211  
Wnt signaling pathway  hsa04310+11211  
According to Reactome, this protein belongs to the following pathway:
Class B/2 (Secretin family receptors)  REACT_18372  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FZD10
GenomeRNAi: 11211
PRO: PR:Q9ULW2