APLN - Apelin - human protein (Function)
 
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Protein
Gene
References

 
APLN »  Apelin
 
Cleaved into:  Apelin-13; Apelin-28; Apelin-31; Apelin-36.
Gene name:  APLN
Family name: Apelin
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 106 1
GENE REF ISO

Function

 show evidences
Overview 
Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.  
1
  • CuratedUniProtKB
GO molecular function 
Apelin receptor bindingdefinition[GO:0031704] silver  
  • IEAOrtholog Compara
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
Receptor bindingdefinition[GO:0005102]  
2
  • TASPINC
GO biological process 
Drinking behaviordefinition[GO:0042756] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Lactationdefinition[GO:0007595]  
1
  • TASPINC
Negative regulation of blood pressuredefinition[GO:0045776] silver  
  • IEAOrtholog Compara
Negative regulation of vasoconstrictiondefinition[GO:0045906] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of corticotropin secretiondefinition[GO:0051461] silver  
  • IEAOrtholog Compara
Positive regulation of corticotropin-releasing hormone secretiondefinition[GO:0051466] silver  
  • IEAOrtholog Compara
Positive regulation of heat generationdefinition[GO:0031652] silver  
  • IEAOrtholog Compara
Positive regulation of phosphorylationdefinition[GO:0042327] silver  
  • IEAOrtholog Compara
Positive regulation of vasodilationdefinition[GO:0045909] silver  
  • IEAOrtholog Compara
Regulation of respiratory gaseous exchangedefinition[GO:0043576] silver  
  • IEAOrtholog Compara
Regulation of the force of heart contractiondefinition[GO:0002026] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apelin
GenomeRNAi: 8862
PRO: PR:Q9ULZ1