STAP1 - Signal-transducing adaptor protein 1 - human protein (Function)
 
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STAP1 »  Signal-transducing adaptor protein 1  (STAP-1)
 
Protein also known as:  BCR downstream-signaling protein 1.
Gene name:  STAP1
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

 show evidences
Overview 
In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.  
2
  • UniProtKB
GO molecular function 
Phospholipid bindingdefinition[GO:0005543]  
1
  • BHF-UCL
Phosphotyrosine bindingdefinition[GO:0001784]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • BHF-UCL
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • BHF-UCL
Transmembrane receptor protein tyrosine kinase adaptor activitydefinition[GO:0005068]  
1
  • Ortholog Curator
GO biological process 
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • Ortholog Curator
Negative regulation of glial cell migrationdefinition[GO:1903976]  
1
  • Ortholog Curator
Negative regulation of macrophage chemotaxisdefinition[GO:0010760]  
1
  • Ortholog Curator
Negative regulation of macrophage colony-stimulating factor signaling pathwaydefinition[GO:1902227]  
1
  • Ortholog Curator
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • Ortholog Curator
Negative regulation of ruffle assemblydefinition[GO:1900028]  
1
  • Ortholog Curator
Positive regulation of actin cytoskeleton reorganizationdefinition[GO:2000251]  
1
  • Ortholog Curator
Positive regulation of B cell receptor signaling pathwaydefinition[GO:0050861]  
1
  • BHF-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • Ortholog Curator
Positive regulation of microglial cell activationdefinition[GO:1903980]  
1
  • Ortholog Curator
Positive regulation of non-membrane spanning protein tyrosine kinase activitydefinition[GO:1903997]  
1
  • BHF-UCL
Positive regulation of phagocytosis, engulfmentdefinition[GO:0060100]  
1
  • Ortholog Curator
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • Ortholog Curator
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STAP1
GenomeRNAi: 26228
PRO: PR:Q9ULZ2