MMP17 - Matrix metalloproteinase-17 - human protein (Function)
 
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MMP17 »  Matrix metalloproteinase-17   [ EC 3.4.24.- ]  (MMP-17)
 
Protein also known as:  Membrane-type matrix metalloproteinase 4 (MTMMP4).
Gene name:  MMP17
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 2
GENE REF ISO

Function

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Overview 
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Enzyme activator activitydefinition[GO:0008047]  
1
  • TASPINC
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • TASGOC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.-: Cleaves pro-TNF-alpha at the 74-Ala-|-Gln-75 site.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
Calcium (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MMP17
GenomeRNAi: 4326
PRO: PR:Q9ULZ9