NOTCH3 - Neurogenic locus notch homolog protein 3 - human protein (Function)
 
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Protein
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NOTCH3 »  Neurogenic locus notch homolog protein 3  (Notch 3)
 
Cleaved into:  Notch 3 extracellular truncation; Notch 3 intracellular domain.
Gene name:  NOTCH3
Family name: NOTCH
Entry whose protein(s) existence is based on evidence at protein level
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1 203 1
GENE REF ISO

Function

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Overview 
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
Glomerular capillary formationdefinition[GO:0072104] silver  
  • IEAOrtholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
  • IEAOrtholog Compara
Neuron fate commitmentdefinition[GO:0048663] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dorso-ventral axis formation  hsa04320+4854  
Notch signaling pathway  hsa04330+4854  
According to Reactome, this protein belongs to the following pathways:
A third proteolytic cleavage releases NICD  REACT_691  
Gene Expression  REACT_71  
NICD traffics to nucleus  REACT_2155  
Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor  REACT_2001  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Notch signaling pathway  definition   [KW-0914]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Notch_3
GenomeRNAi: 4854
PRO: PR:Q9UM47