TBX20 - T-box transcription factor TBX20 - human protein (Function)
 
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TBX20 »  T-box transcription factor TBX20  (T-box protein 20)
 
Gene name:  TBX20
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart (By similarity).  
  • CuratedUniProtKB
GO molecular function 
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
  • ISSOrtholog Curator
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDABHF-UCL
RNA polymerase II transcription coactivator activitydefinition[GO:0001105]  
1
  • IDABHF-UCL
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Aortic valve morphogenesisdefinition[GO:0003180]  
2
  • IMPBHF-UCL
Atrial septum morphogenesisdefinition[GO:0060413]  
3
  • IMPBHF-UCL
Blood circulationdefinition[GO:0008015] silver  
  • IEAOrtholog Compara
Cardiac chamber formationdefinition[GO:0003207]  
  • ISSOrtholog Curator
Cardiac muscle tissue morphogenesisdefinition[GO:0055008]  
  • ISSOrtholog Curator
Cardiac right ventricle morphogenesisdefinition[GO:0003215]  
  • ISSOrtholog Curator
Cardiac septum developmentdefinition[GO:0003279]  
  • ISSOrtholog Curator
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953]  
  • ISSOrtholog Curator
Embryonic heart tube elongationdefinition[GO:0036306] silver  
  • IEAOrtholog Compara
Embryonic heart tube morphogenesisdefinition[GO:0003143]  
  • ISSOrtholog Curator
Endocardial cushion formationdefinition[GO:0003272]  
  • ISSOrtholog Curator
Endocardial cushion morphogenesisdefinition[GO:0003203]  
  • ISSOrtholog Curator
Endoderm formationdefinition[GO:0001706]  
  • ISSOrtholog Curator
Foramen ovale closuredefinition[GO:0035922]  
1
  • IMPBHF-UCL
Heart loopingdefinition[GO:0001947]  
  • ISSOrtholog Curator
Lateral mesoderm formationdefinition[GO:0048370]  
  • ISSOrtholog Curator
Muscle contractiondefinition[GO:0006936] silver  
  • IEAOrtholog Compara
Negative regulation of SMAD protein complex assemblydefinition[GO:0010991] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Outflow tract septum morphogenesisdefinition[GO:0003148]  
2
  • IMPBHF-UCL
Patterning of blood vesselsdefinition[GO:0001569] silver  
  • IEAOrtholog Compara
Pericardium morphogenesisdefinition[GO:0003344]  
  • ISSOrtholog Curator
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAGOC
Pulmonary valve formationdefinition[GO:0003193]  
  • ISSOrtholog Curator
Pulmonary vein morphogenesisdefinition[GO:0060577]  
1
  • IMPBHF-UCL
Tricuspid valve developmentdefinition[GO:0003175]  
  • ISSOrtholog Curator
Visceral motor neuron differentiationdefinition[GO:0021524]  
  • ISSOrtholog Curator
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 57057
PRO: PR:Q9UMR3