USP18 - Ubl carboxyl-terminal hydrolase 18 - human protein (Function)
 
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Protein
Gene
References

 
USP18 »  Ubl carboxyl-terminal hydrolase 18   [ EC 3.4.19.- ]
 
Protein also known as:  ISG15-specific-processing protease.
Gene name:  USP18
Family name: Peptidase C19
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Ubiquitin thiolesterase activitydefinition[GO:0004221] silver  
  • IEAInterPro 2 GO
Ubiquitin-specific protease activitydefinition[GO:0004843]  
1
  • TASPINC
GO biological process 
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.-: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: USP18
GenomeRNAi: 11274
PRO: PR:Q9UMW8