GABRQ - Gamma-aminobutyric acid receptor subunit theta - human protein (Function)
 
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GABRQ »  Gamma-aminobutyric acid receptor subunit theta
 
Protein also known as:  GABA(A) receptor subunit theta.
Gene name:  GABRQ
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 26 1
GENE REF ISO

Function

 show evidences
Overview 
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.  
  • CuratedUniProtKB
GO molecular function 
Chloride channel activitydefinition[GO:0005254]  
  • IEAUniProtKB KW
Extracellular ligand-gated ion channel activitydefinition[GO:0005230] silver  
  • IEAInterPro 2 GO
GABA-A receptor activitydefinition[GO:0004890] silver  
  • IEAInterPro 2 GO
Neurotransmitter transporter activitydefinition[GO:0005326]  
1
  • TASPINC
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
GO biological process 
Neurotransmitter transportdefinition[GO:0006836]  
1
  • TASGOC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+55879  
Neuroactive ligand-receptor interaction  hsa04080+55879  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GABRQ
GenomeRNAi: 55879
PRO: PR:Q9UN88
Chemistry
GuidetoPHARMACOLOGY: 418