ADAMTS5 - A disintegrin and metalloproteinase with thrombospondin motifs 5 - human protein (Function)
 
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ADAMTS5 »  A disintegrin and metalloproteinase with thrombospondin motifs 5   [ EC 3.4.24.- ]  (ADAMTS-5)
 
Protein also known as:  A disintegrin and metalloproteinase with thrombospondin motifs 11 (ADAMTS-11).
Gene name:  ADAMTS5
Entry whose protein(s) existence is based on evidence at protein level
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1 68 1
GENE REF ISO

Function

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Overview 
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.  
  • CuratedUniProtKB
GO molecular function 
Integrin bindingdefinition[GO:0005178]  
1
  • TASPINC
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Metallopeptidase activitydefinition[GO:0008237]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Proteolysisdefinition[GO:0006508]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.-: Cleaves aggrecan at the 392-Glu-|-Ala-393 site.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_223425  
Extracellular matrix organization  REACT_118779  
Metabolism of proteins  REACT_17015  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAMTS5
GenomeRNAi: 11096
PRO: PR:Q9UNA0