STUB1 - E3 ubiquitin-protein ligase CHIP - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
STUB1 »  E3 ubiquitin-protein ligase CHIP   [ EC 6.3.2.- ]
 
Protein also known as:  STIP1 homology and U box-containing protein 1.
Gene name:  STUB1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 135 2
GENE REF ISO

Function

 show evidences
Overview 
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.  
7
  • CuratedUniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Hsp70 protein bindingdefinition[GO:0030544]  
1
  • IDAHGNC
Hsp90 protein bindingdefinition[GO:0051879]  
1
  • IDABHF-UCL
Kinase bindingdefinition[GO:0019900]  
1
  • IPIBHF-UCL
Misfolded protein bindingdefinition[GO:0051787]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
12
  • IPIUniProtKB
  • IPIIntAct
  • IPIHGNC
Protein binding, bridgingdefinition[GO:0030674]  
1
  • TASHGNC
Protein homodimerization activitydefinition[GO:0042803]  
  • ISSOrtholog Curator
SMAD bindingdefinition[GO:0046332]  
1
  • IDAHGNC
TPR domain bindingdefinition[GO:0030911]  
1
  • IDAHGNC
Ubiquitin protein ligase bindingdefinition[GO:0031625] silver  
  • IEAOrtholog Compara
Ubiquitin-protein ligase activitydefinition[GO:0004842]  
4
  • IMPUniProtKB
  • IDAParkinsonsUK-UCL
  • TASHGNC
Ubiquitin-ubiquitin ligase activitydefinition[GO:0034450]  
  • ISSOrtholog Curator
GO biological process 
Cellular response to misfolded proteindefinition[GO:0071218]  
1
  • IDABHF-UCL
DNA repairdefinition[GO:0006281]  
  • IEAUniProtKB KW
Misfolded or incompletely synthesized protein catabolic processdefinition[GO:0006515]  
1
  • IDABHF-UCL
Positive regulation of chaperone-mediated protein complex assemblydefinition[GO:0090035]  
1
  • IDABHF-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
1
  • IDAHGNC
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
2
  • IDABHF-UCL
  • IDAHGNC
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
1
  • IDAHGNC
Protein autoubiquitinationdefinition[GO:0051865]  
2
  • IDAUniProtKB
Protein K63-linked ubiquitinationdefinition[GO:0070534]  
1
  • IDAUniProtKB
Protein maturationdefinition[GO:0051604]  
1
  • TASHGNC
Protein polyubiquitinationdefinition[GO:0000209]  
3
  • IMPUniProtKB
  • IDAParkinsonsUK-UCL
  • IDAHGNC
Regulation of glucocorticoid metabolic processdefinition[GO:0031943]  
1
  • IDAHGNC
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
1
  • IMPUniProtKB
Ubiquitin-dependent SMAD protein catabolic processdefinition[GO:0030579]  
1
  • IDAHGNC
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Protein processing in endoplasmic reticulum  hsa04141+10273  
Ubiquitin mediated proteolysis  hsa04120+10273  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STUB1
GenomeRNAi: 10273
PRO: PR:Q9UNE7