CELA1 - Chymotrypsin-like elastase family member 1 - human protein (Function)
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CELA1 »  Chymotrypsin-like elastase family member 1   [ EC ]
Protein also known as:  Pancreatic elastase 1.
Gene name:  CELA1
Family name: Peptidase S1 » Elastase
Entry whose protein(s) existence is based on evidence at protein level
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Acts upon elastin.  
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
GO biological process 
Exocrine pancreas developmentdefinition[GO:0031017] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Pancreas morphogenesisdefinition[GO:0061113] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Regulation of cell differentiationdefinition[GO:0045595] silver  
  • IEAOrtholog Compara
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Wnt signaling pathwaydefinition[GO:0016055] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 calcium ion per subunit (By similarity).  
  • CuratedUniProtKB
More information is available from:
In spite of its original name "Pancreatic elastase 1", CELA1 is not detected in the pancreas. Elastase activity described in the pancreas may be in fact due to CELA2A (PubMed10620133).  
  • CuratedUniProtKB


Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: CELA1
GenomeRNAi: 1990