CELA1 - Chymotrypsin-like elastase family member 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
CELA1 »  Chymotrypsin-like elastase family member 1   [ EC 3.4.21.36 ]
 
Protein also known as:  Pancreatic elastase 1.
Gene name:  CELA1
Family name: Peptidase S1 » Elastase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 17 1
GENE REF ISO

Function

 show evidences
Overview 
Acts upon elastin.  
1
  • UniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
1
  • InterPro 2 GO
GO biological process 
Exocrine pancreas developmentdefinition[GO:0031017] silver  
1
  • Ortholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Pancreas morphogenesisdefinition[GO:0061113] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
1
  • Ortholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB KW
Regulation of cell differentiationdefinition[GO:0045595] silver  
1
  • Ortholog Compara
Regulation of cell proliferationdefinition[GO:0042127] silver  
1
  • Ortholog Compara
Wnt signaling pathwaydefinition[GO:0016055] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.36: Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.  
1
  • UniProtKB
It requires the following cofactor
 Ca(2+) : Binds 1 Ca(2+) ion per subunit.  
1
  • UniProtKB
 
More information is available from:
Caution 
In spite of its original name "Pancreatic elastase 1", CELA1 is not detected in the pancreas. Elastase activity described in the pancreas may be in fact due to CELA2A (PubMed10620133).  
2
  • UniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CELA1
GenomeRNAi: 1990
PRO: PR:Q9UNI1