PPIE - Peptidyl-prolyl cis-trans isomerase E - human protein (Function)
 
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PPIE »  Peptidyl-prolyl cis-trans isomerase E   [ EC 5.2.1.8 ]  (PPIase E)
 
Protein also known as:  Cyclophilin-33.
Gene name:  PPIE
Entry whose protein(s) existence is based on evidence at protein level
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1 25 3
GENE REF ISO

Function

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Overview 
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.  
  • CuratedUniProtKB
GO molecular function 
Cyclosporin A bindingdefinition[GO:0016018]  
1
  • TASPINC
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
1
  • TASUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
RNA bindingdefinition[GO:0003723]  
1
  • TASUniProtKB
GO biological process 
mRNA splicing, via spliceosomedefinition[GO:0000398]  
1
  • ICUniProtKB
Positive regulation of viral genome replicationdefinition[GO:0045070]  
1
  • IMPUniProtKB
Protein foldingdefinition[GO:0006457]  
  • IEAUniProtKB KW
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
1
  • TASGOC
  • IEAInterPro 2 GO
  • IEAEC 2 GO
  • IEAUniProtKB KW
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Spliceosome  hsa03040+10450  
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPIE_(gene)
GenomeRNAi: 10450
PRO: PR:Q9UNP9