PPIE - Peptidyl-prolyl cis-trans isomerase E - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
PPIE »  Peptidyl-prolyl cis-trans isomerase E   [ EC 5.2.1.8 ]  (PPIase E)
 
Protein also known as:  Cyclophilin-33.
Gene name:  PPIE
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 28 3
GENE REF ISO

Function

 show evidences
Overview 
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.  
1
  • UniProtKB
GO molecular function 
Cyclosporin A bindingdefinition[GO:0016018]  
1
  • PINC
Nucleotide bindingdefinition[GO:0000166] silver  
1
  • InterPro 2 GO
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
RNA bindingdefinition[GO:0003723]  
1
  • UniProtKB
GO biological process 
mRNA splicing, via spliceosomedefinition[GO:0000398]  
1
  • UniProtKB
Positive regulation of viral genome replicationdefinition[GO:0045070]  
1
  • UniProtKB
Protein foldingdefinition[GO:0006457] silver  
1
  • InterPro 2 GO
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413] silver  
1
  • InterPro 2 GO
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Spliceosome  hsa03040+10450  
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPIE_(gene)
GenomeRNAi: 10450
PRO: PR:Q9UNP9