ABCG2 - ATP-binding cassette sub-family G member 2 - human protein (Function)
 
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Protein
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References

 
ABCG2 »  ATP-binding cassette sub-family G member 2
 
Protein also known as:  Placenta-specific ATP-binding cassette transporter; CD antigen CD338.
Gene name:  ABCG2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 432 2
GENE REF ISO

Function

 show evidences
Overview 
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.204.2  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
Transporter activitydefinition[GO:0005215]  
2
  • TASPINC
Xenobiotic-transporting ATPase activitydefinition[GO:0008559]  
1
  • TASPINC
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
  • IEAInterPro 2 GO
Response to drugdefinition[GO:0042493]  
1
  • TASPINC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Urate metabolic processdefinition[GO:0046415]  
3
  • IMPUniProtKB
  • IMPBHF-UCL
Xenobiotic transportdefinition[GO:0042908]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+9429  
Bile secretion  hsa04976+9429  
According to Reactome, this protein belongs to the following pathways:
Abacavir transmembrane transport  REACT_120801  
Iron uptake and transport  REACT_25060  
Note 
When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCG2
GenomeRNAi: 9429
PRO: PR:Q9UNQ0