GPR132 - Probable G-protein coupled receptor 132 - human protein (Function)
 
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GPR132 »  Probable G-protein coupled receptor 132
 
Protein also known as:  G2 accumulation protein.
Gene name:  GPR132
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.  
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  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
GO biological process 
G1/S transition of mitotic cell cycledefinition[GO:0000082] silver  
  • IEAOrtholog Compara
Response to stressdefinition[GO:0006950]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Caution 
Was originally (PubMed11474113) thought to be a receptor for lysophosphatidylcholine (LPC) and sphingosylphosphorylcholine (SPC), However, this work has been retracted.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GPR132
GenomeRNAi: 29933
PRO: PR:Q9UNW8
Chemistry
GuidetoPHARMACOLOGY: 128