GPR132 - Probable G-protein coupled receptor 132 - human protein (Function)
 
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Protein
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References

 
GPR132 »  Probable G-protein coupled receptor 132
 
Protein also known as:  G2 accumulation protein.
Gene name:  GPR132
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication.  
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  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
GO biological process 
G1/S transition of mitotic cell cycledefinition[GO:0000082] silver  
  • IEAOrtholog Compara
Response to stressdefinition[GO:0006950]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Caution 
Was originally (PubMed11474113) thought to be a receptor for lysophosphatidylcholine (LPC) and sphingosylphosphorylcholine (SPC), However, this work has been retracted.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GPR132
GenomeRNAi: 29933
PRO: PR:Q9UNW8
Chemistry
GuidetoPHARMACOLOGY: 128