KCNJ14 - ATP-sensitive inward rectifier potassium channel 14 - human protein (Function)
 
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Protein
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KCNJ14 »  ATP-sensitive inward rectifier potassium channel 14
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 14.
Gene name:  KCNJ14
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 14 1
GENE REF ISO

Function

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Overview 
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Inward rectifier potassium channel activitydefinition[GO:0005242] silver  
  • IEAOrtholog Compara
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • TASGOC
  • IEAOrtholog Compara
  • IEAInterPro 2 GO
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cholinergic synapse  hsa04725+3770  
According to Reactome, this protein belongs to the following pathway:
Classical Kir channels  REACT_75870  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNJ14
GenomeRNAi: 3770
PRO: PR:Q9UNX9
Chemistry
GuidetoPHARMACOLOGY: 433