FZD1 - Frizzled-1 - human protein (Function)
 
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FZD1 »  Frizzled-1  (Fz-1)
 
Protein also known as:  FzE1.
Gene name:  FZD1
Entry whose protein(s) existence is based on evidence at protein level
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1 32 1
GENE REF ISO

Function

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Overview 
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.16.1  
GO molecular function 
Frizzled bindingdefinition[GO:0005109]  
1
  • IPIUniProtKB
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
PDZ domain bindingdefinition[GO:0030165]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIBHF-UCL
Wnt-activated receptor activitydefinition[GO:0042813]  
1
  • IDABHF-UCL
Wnt-protein bindingdefinition[GO:0017147]  
1
  • IPIBHF-UCL
GO biological process 
Autocrine signalingdefinition[GO:0035425]  
1
  • IDABHF-UCL
Axonogenesisdefinition[GO:0007409] silver  
  • IBARefGenome
Brain developmentdefinition[GO:0007420] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Canonical Wnt signaling pathway involved in mesenchymal stem cell differentiationdefinition[GO:0044338]  
1
  • IMPBHF-UCL
Canonical Wnt signaling pathway involved in osteoblast differentiationdefinition[GO:0044339]  
1
  • IMPBHF-UCL
Cell-cell signalingdefinition[GO:0007267]  
1
  • IDABHF-UCL
Epithelial cell differentiationdefinition[GO:0030855] silver  
  • IBARefGenome
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerdefinition[GO:0007199] silver  
  • IBARefGenome
Gonad developmentdefinition[GO:0008406] silver  
  • IBARefGenome
Hard palate developmentdefinition[GO:0060022] silver  
  • IEAOrtholog Compara
Lung alveolus developmentdefinition[GO:0048286] silver  
  • IBARefGenome
Membranous septum morphogenesisdefinition[GO:0003149] silver  
  • IEAOrtholog Compara
Muscular septum morphogenesisdefinition[GO:0003150] silver  
  • IEAOrtholog Compara
Negative regulation of BMP signaling pathwaydefinition[GO:0030514] silver  
  • IBARefGenome
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090] silver  
  • IBARefGenome
Negative regulation of catenin import into nucleusdefinition[GO:0035414] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
Outflow tract morphogenesisdefinition[GO:0003151] silver  
  • IEAOrtholog Compara
Planar cell polarity pathway involved in neural tube closuredefinition[GO:0090179] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
2
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDABHF-UCL
Response to drugdefinition[GO:0042493]  
1
  • IMPBHF-UCL
Vasculature developmentdefinition[GO:0001944] silver  
  • IBARefGenome
Wnt signaling pathway, calcium modulating pathwaydefinition[GO:0007223] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+8321  
HTLV-I infection  hsa05166+8321  
Melanogenesis  hsa04916+8321  
Pathways in cancer  hsa05200+8321  
Wnt signaling pathway  hsa04310+8321  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: FZD1
GenomeRNAi: 8321
PRO: PR:Q9UP38
Chemistry
GuidetoPHARMACOLOGY: 229