ADAMTS8 - A disintegrin and metalloproteinase with thrombospondin motifs 8 - human protein (Function)
 
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ADAMTS8 »  A disintegrin and metalloproteinase with thrombospondin motifs 8   [ EC 3.4.24.- ]  (ADAMTS-8)
 
Protein also known as:  METH-8.
Gene name:  ADAMTS8
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 23 1
GENE REF ISO

Function

 show evidences
Overview 
Has anti-angiogenic properties.  
  • CuratedUniProtKB
GO molecular function 
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
Integrin bindingdefinition[GO:0005178]  
1
  • TASPINC
Low affinity phosphate transmembrane transporter activitydefinition[GO:0009673]  
1
  • TASPINC
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Metallopeptidase activitydefinition[GO:0008237]  
1
  • TASPINC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Anion transportdefinition[GO:0006820]  
1
  • TASGOC
Inorganic anion transportdefinition[GO:0015698]  
1
  • TASGOC
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Phosphate ion transmembrane transportdefinition[GO:0035435]  
1
  • TASGOC
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Transmembrane transportdefinition[GO:0055085]  
1
  • TASGOC
Transportdefinition[GO:0006810]  
1
  • TASGOC
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_133391  
Extracellular matrix organization  REACT_118779  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAMTS8
GenomeRNAi: 11095
PRO: PR:Q9UP79