SLC12A4 - Solute carrier family 12 member 4 - human protein (Function)
 
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Protein
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References

 
SLC12A4 »  Solute carrier family 12 member 4
 
Protein also known as:  Electroneutral potassium-chloride cotransporter 1.
Gene name:  SLC12A4
Family name: SLC12A transporter
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 7
GENE REF ISO

Function

 show evidences
Overview 
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity).  
  • UniProtKB
Isoform  Iso 4   Has no transport activity.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the cation-chloride cotransporter (ccc) family  2.A.30.5.5  
GO molecular function 
Potassium:chloride symporter activitydefinition[GO:0015379] silver  
1
  • InterPro 2 GO
Protein kinase bindingdefinition[GO:0019901]  
1
  • ParkinsonsUK-UCL
GO biological process 
Cell volume homeostasisdefinition[GO:0006884]  
1
  • PINC
Chloride transmembrane transportdefinition[GO:1902476]  
2
  • GOC
  • InterPro 2 GO
Chloride transportdefinition[GO:0006821]  
1
  • GOC
Potassium ion transportdefinition[GO:0006813]  
1
  • UniProtKB KW
Transportdefinition[GO:0006810]  
1
  • PINC
Enzymatic activity 
It is regulated in the following manner
Inhibited by WNK3.  
2
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cation-coupled Chloride cotransporters  REACT_19315  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Chloride_potassium_symporter_4
GenomeRNAi: 6560
PRO: PR:Q9UP95
Chemistry
GuidetoPHARMACOLOGY: 971