SRPK3 - SRSF protein kinase 3 - human protein (Function)
 
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SRPK3 »  SRSF protein kinase 3   [ EC 2.7.11.1 ]
 
Protein also known as:  Serine/arginine-rich protein-specific kinase 3 (SR-protein-specific kinase 3).
Gene name:  SRPK3
Entry whose protein(s) existence is based on evidence at protein level
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1 19 4
GENE REF ISO

Function

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Overview 
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674] silver  
  • IEAOrtholog Compara
GO biological process 
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Muscle tissue developmentdefinition[GO:0060537]  
  • ISSOrtholog Curator
Skeletal muscle tissue developmentdefinition[GO:0007519] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Myogenesis  definition   [KW-0517]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 26576
PRO: PR:Q9UPE1
Chemistry
GuidetoPHARMACOLOGY: 2210