DOLK - Dolichol kinase - human protein (Function)
 
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DOLK »  Dolichol kinase   [ EC 2.7.1.108 ]
 
Protein also known as:  Transmembrane protein 15.
Gene name:  DOLK
Family name: Polyprenol kinase
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

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Overview 
Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Dolichol kinase activitydefinition[GO:0004168]  
2
  • IDAUniProtKB
GO biological process 
Dolichyl monophosphate biosynthetic processdefinition[GO:0043048]  
2
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.108: CTP + dolichol CDP + dolichyl phosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+22845  
N-Glycan biosynthesis  hsa00510+22845  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
Note 
Complements the defects in growth, dolichol kinase activity and protein N-glycosylation at the restrictive temperature in yeast sec59 mutant cells.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Dolichol_kinase
GenomeRNAi: 22845
PRO: PR:Q9UPQ8