USP22 - Ubiquitin carboxyl-terminal hydrolase 22 - human protein (Function)
 
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USP22 »  Ubiquitin carboxyl-terminal hydrolase 22   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease 22.
Gene name:  USP22
Family name: Peptidase C19 » UBP8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.  
4
  • UniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • RefGenome
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Contributes to H4 histone acetyltransferase activitydefinition[GO:0010485]  
1
  • UniProtKB
Ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:0030374]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • UniProtKB
Contributes to ubiquitin-specific protease activitydefinition[GO:0004843]  
2
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cell cycledefinition[GO:0007049]  
1
  • UniProtKB KW
Embryo developmentdefinition[GO:0009790]  
1
  • UniProtKB
Histone deubiquitinationdefinition[GO:0016578]  
2
  • UniProtKB
Histone H4 acetylationdefinition[GO:0043967]  
1
  • GOC
Histone ubiquitinationdefinition[GO:0016574]  
1
  • UniProtKB
Positive regulation of mitotic cell cycledefinition[GO:0045931]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
1
  • RefGenome
Protein deubiquitinationdefinition[GO:0016579]  
1
  • UniProtKB
Regulation of proteasomal protein catabolic processdefinition[GO:0061136]  
1
  • RefGenome
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
HATs acetylate histones  REACT_264245  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Activator  definition   [KW-0010]
Chromatin regulator  definition   [KW-0156]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23326
PRO: PR:Q9UPT9