USP22 - Ubiquitin carboxyl-terminal hydrolase 22 - human protein (Function)
 
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USP22 »  Ubiquitin carboxyl-terminal hydrolase 22   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease 22.
Gene name:  USP22
Family name: Peptidase C19 » UBP8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 2
GENE REF ISO

Function

 show evidences
Overview 
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.  
3
  • CuratedUniProtKB
GO molecular function 
Contributes to H4 histone acetyltransferase activitydefinition[GO:0010485]  
1
  • IDAUniProtKB
Ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:0030374]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • IDAUniProtKB
Contributes to ubiquitin-specific protease activitydefinition[GO:0004843]  
2
  • IMPUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Embryo developmentdefinition[GO:0009790]  
1
  • NASUniProtKB
Histone deubiquitinationdefinition[GO:0016578]  
2
  • IDAUniProtKB
Histone H4 acetylationdefinition[GO:0043967]  
1
  • IDAGOC
Histone ubiquitinationdefinition[GO:0016574]  
1
  • IDAUniProtKB
Positive regulation of mitotic cell cycledefinition[GO:0045931]  
1
  • IMPUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IMPUniProtKB
Protein deubiquitinationdefinition[GO:0016579]  
1
  • IDAUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Chromatin organization  REACT_172623  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Activator  definition   [KW-0010]
Chromatin regulator  definition   [KW-0156]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23326
PRO: PR:Q9UPT9