SATB2 - DNA-binding protein SATB2 - human protein (Function)
 
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SATB2 »  DNA-binding protein SATB2
 
Protein also known as:  Special AT-rich sequence-binding protein 2.
Gene name:  SATB2
Family name: CUT homeobox
Entry whose protein(s) existence is based on evidence at protein level
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1 43 2
GENE REF ISO

Function

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Overview 
Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Cartilage developmentdefinition[GO:0051216] silver  
  • IEAOrtholog Compara
Cellular response to organic substancedefinition[GO:0071310] silver  
  • IEAOrtholog Compara
Chromatin remodelingdefinition[GO:0006338] silver  
  • IEAOrtholog Compara
Embryonic pattern specificationdefinition[GO:0009880] silver  
  • IEAOrtholog Compara
Embryonic skeletal system morphogenesisdefinition[GO:0048704] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Osteoblast developmentdefinition[GO:0002076] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SATB2
GenomeRNAi: 23314
PRO: PR:Q9UPW6