ICK - Serine/threonine-protein kinase ICK - human protein (Function)
 
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ICK »  Serine/threonine-protein kinase ICK   [ EC 2.7.11.22 ]
 
Protein also known as:  Laryngeal cancer kinase 2 (LCK2).
Gene name:  ICK
Entry whose protein(s) existence is based on evidence at protein level
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1 42 2
GENE REF ISO

Function

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Overview 
Required for ciliogenesis (PubMed24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity).  
5
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
1
  • EC 2 GO
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB
GO biological process 
Cilium assemblydefinition[GO:0042384]  
1
  • UniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • UniProtKB
Intraciliary transportdefinition[GO:0042073]  
1
  • Ortholog Curator
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • UniProtKB KW
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of cell cycledefinition[GO:0051726]  
1
  • EC 2 GO
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
 

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ICK_(gene)
GenomeRNAi: 22858
PRO: PR:Q9UPZ9
Chemistry
GuidetoPHARMACOLOGY: 2038