NEU3 - Sialidase-3 - human protein (Function)
 
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Protein
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NEU3 »  Sialidase-3   [ EC 3.2.1.18 ]
 
Protein also known as:  N-acetyl-alpha-neuraminidase 3.
Gene name:  NEU3
Family name: Glycosyl hydrolase 33
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 2
GENE REF ISO

Function

 show evidences
Overview 
Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.  
2
  • CuratedUniProtKB
GO molecular function 
Alpha-sialidase activitydefinition[GO:0016997]  
1
  • IDAMGI
Exo-alpha-(2->3)-sialidase activitydefinition[GO:0052794]  
  • ISSOrtholog Curator
Exo-alpha-(2->6)-sialidase activitydefinition[GO:0052795]  
  • IEAEC 2 GO
Exo-alpha-(2->8)-sialidase activitydefinition[GO:0052796]  
  • ISSOrtholog Curator
Exo-alpha-sialidase activitydefinition[GO:0004308]  
1
  • IDAUniProtKB
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • IDAMGI
Ganglioside catabolic processdefinition[GO:0006689]  
1
  • IDAUniProtKB
Oligosaccharide catabolic processdefinition[GO:0009313]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.1.18: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.  
2
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 33  GH33  
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Glycosphingolipid metabolism  REACT_116105  
Sialic acid metabolism  REACT_200874  
 

Biophysicochemical properties

Dependence
pH Optimum pH is 3.8.

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9UQ49
Other
GeneWiki: NEU3
PRO: PR:Q9UQ49