CDK11A - Cyclin-dependent kinase 11A - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CDK11A »  Cyclin-dependent kinase 11A   [ EC 2.7.11.22 ]
 
Protein also known as:  Galactosyltransferase-associated protein kinase p58/GTA.
Gene name:  CDK11A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 18 8
GENE REF ISO

Function

 show evidences
Overview 
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
  • IEAEC 2 GO
Protein kinase activitydefinition[GO:0004672]  
1
  • NASUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • NASUniProtKB
Mitosisdefinition[GO:0007067]  
1
  • NASUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of cell growthdefinition[GO:0001558]  
1
  • IEPUniProtKB
Regulation of mRNA processingdefinition[GO:0050684]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583 activates it (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cell Cycle  REACT_115566  
Note 
Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.  
  • CuratedUniProtKB
Caution 
Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B or one/some of the isoforms of each.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell cycle  definition   [KW-0131]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CDC2L2
GenomeRNAi: 728642
PRO: PR:Q9UQ88
Chemistry
GuidetoPHARMACOLOGY: 1963