BAIAP2 - Brain-specific angiogenesis inhibitor 1-associated protein 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
BAIAP2 »  Brain-specific angiogenesis inhibitor 1-associated protein 2  (Protein BAP2)
 
Protein also known as:  Insulin receptor substrate protein of 53 kDa (IRSp53).
Gene name:  BAIAP2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 87 6
GENE REF ISO

Function

 show evidences
Overview 
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.  
6
  • UniProtKB
GO molecular function 
Cytoskeletal adaptor activitydefinition[GO:0008093] silver  
1
  • InterPro 2 GO
Identical protein bindingdefinition[GO:0042802]  
4
  • IntAct
Proline-rich region bindingdefinition[GO:0070064]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
14
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • PINC
GO biological process 
Actin crosslink formationdefinition[GO:0051764]  
2
  • RefGenome
  • Ortholog Curator
Actin filament bundle assemblydefinition[GO:0051017]  
2
  • RefGenome
  • Ortholog Curator
Axonogenesisdefinition[GO:0007409]  
1
  • PINC
Dendrite developmentdefinition[GO:0016358] silver  
1
  • Ortholog Compara
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • PINC
Plasma membrane organizationdefinition[GO:0007009] silver  
1
  • InterPro 2 GO
Positive regulation of actin cytoskeleton reorganizationdefinition[GO:2000251]  
1
  • RefGenome
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • RefGenome
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • UniProtKB
Regulation of cell shapedefinition[GO:0008360]  
1
  • Ortholog Curator
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
1
  • Ortholog Compara
Response to bacteriumdefinition[GO:0009617]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+10458  
Regulation of actin cytoskeleton  hsa04810+10458  
According to Reactome, this protein belongs to the following pathways:
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
VEGFA-VEGFR2 Pathway  REACT_264464  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BAIAP2
GenomeRNAi: 10458
PRO: PR:Q9UQB8