BAIAP2 - Brain-specific angiogenesis inhibitor 1-associated protein 2 - human protein (Function)
 
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BAIAP2 »  Brain-specific angiogenesis inhibitor 1-associated protein 2  (Protein BAP2)
 
Protein also known as:  Insulin receptor substrate protein of 53 kDa (IRSp53).
Gene name:  BAIAP2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 62 6
GENE REF ISO

Function

 show evidences
Overview 
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.  
5
  • CuratedUniProtKB
GO molecular function 
Cytoskeletal adaptor activitydefinition[GO:0008093] silver  
  • IEAInterPro 2 GO
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Proline-rich region bindingdefinition[GO:0070064]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
10
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • TASPINC
SH3 domain bindingdefinition[GO:0017124] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin crosslink formationdefinition[GO:0051764]  
  • ISSOrtholog Curator
Actin filament bundle assemblydefinition[GO:0051017]  
  • ISSOrtholog Curator
Axonogenesisdefinition[GO:0007409]  
1
  • TASPINC
Dendrite developmentdefinition[GO:0016358] silver  
  • IEAOrtholog Compara
Filopodium assemblydefinition[GO:0046847] silver  
  • IEAInterPro 2 GO
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • TASPINC
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • IMPUniProtKB
Regulation of cell shapedefinition[GO:0008360]  
  • ISSOrtholog Curator
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
  • IEAOrtholog Compara
Response to bacteriumdefinition[GO:0009617]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+10458  
Regulation of actin cytoskeleton  hsa04810+10458  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BAIAP2
GenomeRNAi: 10458
PRO: PR:Q9UQB8