AURKC - Aurora kinase C - human protein (Function)
 
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AURKC »  Aurora kinase C   [ EC 2.7.11.1 ]
 
Protein also known as:  Serine/threonine-protein kinase aurora-C.
Gene name:  AURKC
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.  
6
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein kinase activitydefinition[GO:0004672]  
1
  • IDAUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
1
  • TASUniProtKB
GO biological process 
Attachment of spindle microtubules to kinetochoredefinition[GO:0008608]  
1
  • TASUniProtKB
Cytokinesisdefinition[GO:0000910]  
1
  • TASPINC
Histone modificationdefinition[GO:0016570]  
1
  • TASUniProtKB
Meiosisdefinition[GO:0007126]  
  • IEAUniProtKB KW
Positive regulation of cytokinesisdefinition[GO:0032467]  
1
  • TASUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Spindle midzone assembly involved in mitosisdefinition[GO:0051256]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which acts also as an activator.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Meiosis  definition   [KW-0469]
Mitosis  definition   [KW-0498]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: AURKC
GenomeRNAi: 6795
PRO: PR:Q9UQB9
Chemistry
GuidetoPHARMACOLOGY: 1938