CLCA2 - Calcium-activated chloride channel regulator 2 - human protein (Function)
 
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CLCA2 »  Calcium-activated chloride channel regulator 2
 
Protein also known as:  Calcium-activated chloride channel family member 2. Cleaved into:  Calcium-activated chloride channel regulator 2, 109 kDa form; Calcium-activated chloride channel regulator 2, 35 kDa form.
Gene name:  CLCA2
Family name: CLCR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 1
GENE REF ISO

Function

 show evidences
Overview 
Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.  
5
  • CuratedUniProtKB
GO molecular function 
Chloride channel activitydefinition[GO:0005254] silver  
  • IEAOrtholog Compara
Ligand-gated ion channel activitydefinition[GO:0015276] silver  
  • IEAOrtholog Compara
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • TASGOC
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Olfactory transduction  hsa04740+9635  
Pancreatic secretion  hsa04972+9635  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLCA2
GenomeRNAi: 9635
PRO: PR:Q9UQC9