SCN8A - Sodium channel protein type 8 subunit alpha - human protein (Function)
 
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Protein
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SCN8A »  Sodium channel protein type 8 subunit alpha
 
Protein also known as:  Voltage-gated sodium channel subunit alpha Nav1.6.
Gene name:  SCN8A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 5
GENE REF ISO

Function

 show evidences
Overview 
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.10.8  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Voltage-gated sodium channel activitydefinition[GO:0005248]  
2
  • IDAUniProtKB
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
  • IEAOrtholog Compara
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Muscle organ developmentdefinition[GO:0007517] silver  
  • IEAOrtholog Compara
Myelinationdefinition[GO:0042552]  
  • ISSOrtholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Neuromuscular processdefinition[GO:0050905] silver  
  • IEAOrtholog Compara
Neuronal action potentialdefinition[GO:0019228] silver  
  • IBARefGenome
Peripheral nervous system developmentdefinition[GO:0007422]  
  • ISSOrtholog Curator
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Sensory perception of sounddefinition[GO:0007605] silver  
  • IEAOrtholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
2
  • IDAGOC
  • IEAInterPro 2 GO
  • IEAUniProtKB KW
Sodium ion transportdefinition[GO:0006814]  
1
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interaction between L1 and Ankyrins  REACT_22266  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SCN8A
GenomeRNAi: 6334
PRO: PR:Q9UQD0
Chemistry
GuidetoPHARMACOLOGY: 583