CAMK2A - Calcium/calmodulin-dependent protein kinase type II subunit alpha - human protein (Function)
 
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CAMK2A »  Calcium/calmodulin-dependent protein kinase type II subunit alpha   [ EC 2.7.11.17 ]  (CaMK-II subunit alpha)
 
Gene name:  CAMK2A
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
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  • BHF-UCL
Calmodulin-dependent protein kinase activitydefinition[GO:0004683]  
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  • EC 2 GO
Glutamate receptor bindingdefinition[GO:0035254]  
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  • Ortholog Curator
Kinase activitydefinition[GO:0016301]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
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  • BHF-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • Ortholog Curator
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
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  • Ortholog Curator
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
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  • Ortholog Curator
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
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  • Ortholog Curator
Positive regulation of calcium ion transportdefinition[GO:0051928]  
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  • Ortholog Curator
Positive regulation of cardiac muscle cell apoptotic processdefinition[GO:0010666]  
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  • Ortholog Curator
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
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  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
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  • Ortholog Curator
Protein phosphorylationdefinition[GO:0006468]  
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  • UniProtKB
Regulation of mitochondrial membrane permeability involved in apoptotic processdefinition[GO:1902108]  
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  • Ortholog Curator
Regulation of neuronal synaptic plasticitydefinition[GO:0048168]  
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  • Ortholog Curator
Regulation of neurotransmitter secretiondefinition[GO:0046928]  
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  • Ortholog Curator
Response to ischemiadefinition[GO:0002931]  
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  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.17: ATP + a protein ADP + a phosphoprotein.  
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  • UniProtKB
It is regulated in the following manner
Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.  
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  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+815  
Cholinergic synapse  hsa04725+815  
Dopaminergic synapse  hsa04728+815  
ErbB signaling pathway  hsa04012+815  
Gastric acid secretion  hsa04971+815  
Glioma  hsa05214+815  
GnRH signaling pathway  hsa04912+815  
Long-term potentiation  hsa04720+815  
Melanogenesis  hsa04916+815  
Neurotrophin signaling pathway  hsa04722+815  
Olfactory transduction  hsa04740+815  
Oocyte meiosis  hsa04114+815  
Tuberculosis  hsa05152+815  
Wnt signaling pathway  hsa04310+815  
According to Reactome, this protein belongs to the following pathways:
Ca2+ pathway  REACT_263982  
CREB phosphorylation through the activation of CaMKII  REACT_20642  
CREB phosphorylation through the activation of Ras  REACT_20568  
HSF1-dependent transactivation  REACT_264164  
Interferon gamma signaling  REACT_25078  
Ras activation uopn Ca2+ infux through NMDA receptor  REACT_20546  
Trafficking of AMPA receptors  REACT_18307  
Unblocking of NMDA receptor, glutamate binding and activation  REACT_20594  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CAMK2A
GenomeRNAi: 815
PRO: PR:Q9UQM7
Chemistry
GuidetoPHARMACOLOGY: 1555