CAMK2A - Calcium/calmodulin-dependent protein kinase type II subunit alpha - human protein (Function)
 
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CAMK2A »  Calcium/calmodulin-dependent protein kinase type II subunit alpha   [ EC 2.7.11.17 ]  (CaMK-II subunit alpha)
 
Gene name:  CAMK2A
Entry whose protein(s) existence is based on evidence at protein level
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1 57 2
GENE REF ISO

Function

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Overview 
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Calmodulin-dependent protein kinase activitydefinition[GO:0004683]  
  • IEAEC 2 GO
Glutamate receptor bindingdefinition[GO:0035254] silver  
  • IEAOrtholog Compara
Kinase activitydefinition[GO:0016301]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Calcium ion transportdefinition[GO:0006816] silver  
  • IEAOrtholog Compara
G1/S transition of mitotic cell cycledefinition[GO:0000082] silver  
  • IEAOrtholog Compara
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of neuronal synaptic plasticitydefinition[GO:0048168] silver  
  • IEAOrtholog Compara
Regulation of neurotransmitter secretiondefinition[GO:0046928] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.17: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+815  
Cholinergic synapse  hsa04725+815  
Dopaminergic synapse  hsa04728+815  
ErbB signaling pathway  hsa04012+815  
Gastric acid secretion  hsa04971+815  
Glioma  hsa05214+815  
GnRH signaling pathway  hsa04912+815  
Long-term potentiation  hsa04720+815  
Melanogenesis  hsa04916+815  
Neurotrophin signaling pathway  hsa04722+815  
Olfactory transduction  hsa04740+815  
Oocyte meiosis  hsa04114+815  
Tuberculosis  hsa05152+815  
Wnt signaling pathway  hsa04310+815  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Neuronal System  REACT_13685  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CAMK2A
GenomeRNAi: 815
PRO: PR:Q9UQM7
Chemistry
GuidetoPHARMACOLOGY: 1555