CHMP2B - Charged multivesicular body protein 2b - human protein (Function)
 
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Protein
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References

 
CHMP2B »  Charged multivesicular body protein 2b
 
Protein also known as:  Vacuolar protein sorting-associated protein 2-2 (Vps2-2).
Gene name:  CHMP2B
Family name: SNF7
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Endocytosis  hsa04144+25978  
According to Reactome, this protein belongs to the following pathways:
Budding and maturation of HIV virion  REACT_6359  
Endosomal Sorting Complex Required For Transport (ESCRT)  REACT_27258  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CHMP2B
GenomeRNAi: 25978
PRO: PR:Q9UQN3