APOBEC2 - Probable C->U-editing enzyme APOBEC-2 - human protein (Function)
 
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APOBEC2 »  Probable C->U-editing enzyme APOBEC-2   [ EC 3.5.4.- ]
 
Gene name:  APOBEC2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.  
2
  • UniProtKB
GO molecular function 
Cytidine deaminase activitydefinition[GO:0004126]  
1
  • PINC
RNA bindingdefinition[GO:0003723]  
1
  • PINC
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cytidine deaminationdefinition[GO:0009972]  
1
  • GOC
DNA demethylationdefinition[GO:0080111]  
1
  • UniProtKB
mRNA modificationdefinition[GO:0016556] silver  
1
  • Ortholog Compara
mRNA processingdefinition[GO:0006397]  
1
  • UniProtKB KW
Enzymatic activity 
It requires the following cofactor
 Zn(2+)  
1
  • UniProtKB
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: APOBEC2
GenomeRNAi: 10930
PRO: PR:Q9Y235