PIN4 - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 - human protein (Function)
 
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PIN4 »  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4   [ EC 5.2.1.8 ]
 
Protein also known as:  Peptidyl-prolyl cis-trans isomerase Pin4 (PPIase Pin4).
Gene name:  PIN4
Family name: PpiC/parvulin rotamase » PIN4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 20 3
GENE REF ISO

Function

 show evidences
Overview 
Isoform  Iso 1   Is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.  
1
  • CuratedUniProtKB
Isoform  Iso 2   Binds to double-stranded DNA.  
1
  • CuratedUniProtKB
GO molecular function 
Isoform  Iso 1   Bent DNA bindingdefinition[GO:0003681]  
1
  • IDAUniProtKB
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Isoforms  Iso 1 and Iso 2   Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • IDAUniProtKB
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
  • IEAEC 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
GO biological process 
Protein foldingdefinition[GO:0006457]  
  • IEAUniProtKB KW
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
  • IEAEC 2 GO
  • IEAUniProtKB KW
Isoform  Iso 1   rRNA processingdefinition[GO:0006364]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PIN4
GenomeRNAi: 5303
PRO: PR:Q9Y237