POLH - DNA polymerase eta - human protein (Function)
 
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References

 
POLH »  DNA polymerase eta   [ EC 2.7.7.7 ]
 
Protein also known as:  Xeroderma pigmentosum variant type protein.
Gene name:  POLH
Family name: DNA polymerase type-Y
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci.  
5
  • CuratedUniProtKB
GO molecular function 
Damaged DNA bindingdefinition[GO:0003684] silver  
  • IEAInterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
DNA synthesis involved in DNA repairdefinition[GO:0000731]  
1
  • IDAUniProtKB
DNA-dependent DNA replicationdefinition[GO:0006261]  
2
  • TASGOC
  • IEAInterPro 2 GO
  • IEAEC 2 GO
  • IEAOrtholog Compara
  • IEAUniProtKB KW
Postreplication repairdefinition[GO:0006301] silver  
  • IEAOrtholog Compara
Pyrimidine dimer repairdefinition[GO:0006290] silver  
  • IEAOrtholog Compara
Regulation of DNA repairdefinition[GO:0006282]  
1
  • TASPINC
Response to UV-Cdefinition[GO:0010225]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.7.7: Deoxynucleoside triphosphate + DNA(n) diphosphate + DNA(n+1).  
  • CuratedUniProtKB
It requires the following cofactor
Divalent metal cations. Prefers magnesium, but can also use manganese.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Fanconi anemia pathway  hsa03460+5429  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
DNA replication  definition   [KW-0235]
DNA synthesis  definition   [KW-0237]
Molecular function 
DNA-directed DNA polymerase  definition   [KW-0239]
Mutator protein  definition   [KW-0515]
Nucleotidyltransferase  definition   [KW-0548]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9Y253
Other
GeneWiki: DNA_polymerase_eta
GenomeRNAi: 5429
PRO: PR:Q9Y253