RCE1 - CAAX prenyl protease 2 - human protein (Function)
 
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Protein
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RCE1 »  CAAX prenyl protease 2
 
Gene name:  RCE1
Family name: Peptidase U48
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1.  
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • IDAUniProtKB
Metalloendopeptidase activitydefinition[GO:0004222]  
1
  • TASPINC
GO biological process 
CAAX-box protein processingdefinition[GO:0071586]  
1
  • IMPUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • TASPINC
Enzymatic activity 
It is regulated in the following manner
Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RCE1
PRO: PR:Q9Y256