KCNK6 - Potassium channel subfamily K member 6 - human protein (Function)
 
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Protein
Gene
References

 
KCNK6 »  Potassium channel subfamily K member 6
 
Protein also known as:  Inward rectifying potassium channel protein TWIK-2.
Gene name:  KCNK6
Entry whose protein(s) existence is based on evidence at protein level
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1 13 2
GENE REF ISO

Function

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Overview 
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.8.3  
GO molecular function 
Inward rectifier potassium channel activitydefinition[GO:0005242]  
1
  • TASPINC
GO biological process 
Negative regulation of systemic arterial blood pressuredefinition[GO:0003085] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Regulation of resting membrane potentialdefinition[GO:0060075] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
Note 
Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNK6
GenomeRNAi: 9424
PRO: PR:Q9Y257