CHKB - Choline/ethanolamine kinase - human protein (Function)
 
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CHKB »  Choline/ethanolamine kinase
 
Protein also known as:  choline/ethanolamine kinase beta (CKEKB).
Gene name:  CHKB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Choline kinase activitydefinition[GO:0004103]  
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  • UniProtKB
Ethanolamine kinase activitydefinition[GO:0004305]  
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  • UniProtKB
GO biological process 
CDP-choline pathwaydefinition[GO:0006657]  
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  • GOC
  • EC 2 GO
Phosphatidylethanolamine biosynthetic processdefinition[GO:0006646]  
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  • UniProtKB
  • UniPathway
Phosphorylationdefinition[GO:0016310]  
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  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.1.32: ATP + choline ADP + phosphocholine.  
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  • UniProtKB
EC 2.7.1.82: ATP + ethanolamine ADP + O-phosphoethanolamine.  
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  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3  
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  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Glycerophospholipid metabolism  hsa00564+1120  
Metabolic pathways  hsa01100+1120  
According to Reactome, this protein belongs to the following pathways:
Synthesis of PC  REACT_121238  
Synthesis of PE  REACT_120919  
Note 
This protein is produced by a bicistronic gene which also produces the CPT1B protein from a non-overlapping reading frame.  
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  • UniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 2.9 mM for ethanolamine
KM 0.57 mM for choline

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9Y259
Other
GeneWiki: CHKB_(gene)
GenomeRNAi: 1120
PRO: PR:Q9Y259