ANGPT4 - Angiopoietin-4 - human protein (Function)
 
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ANGPT4 »  Angiopoietin-4  (ANG-4)
 
Protein also known as:  Angiopoietin-3 (ANG-3).
Gene name:  ANGPT4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.  
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  • CuratedUniProtKB
GO molecular function 
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • IDAUniProtKB
Transmembrane receptor protein tyrosine kinase activator activitydefinition[GO:0030297]  
2
  • IDAUniProtKB
GO biological process 
Activation of transmembrane receptor protein tyrosine kinase activitydefinition[GO:0007171]  
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  • IDAGOC
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Cellular response to hypoxiadefinition[GO:0071456]  
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  • IEPUniProtKB
Not  Endothelial cell proliferationdefinition[GO:0001935]  
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  • IDAUniProtKB
Negative regulation of angiogenesisdefinition[GO:0016525]  
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  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
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  • IDAUniProtKB
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • IDAUniProtKB
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IDAUniProtKB
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
1
  • IDAUniProtKB
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • IDAUniProtKB
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Tie2 Signaling  REACT_12621  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ANGPT4
GenomeRNAi: 51378
PRO: PR:Q9Y264